The information presented on the site should not be used for self-diagnosis and treatment and cannot serve as a substitute for an in-person consultation with a dermatologist. Epidermodysplasia verruciformis (Lewandowski-Lutz epidermodysplasia verruciformis) is characterized by chronic human papillomavirus (HPV) infection leading to the development of polymorphic skin lesions and a high risk of developing non-melanoma skin cancer. The MoyMinZdrav system allows you to identify a range of diseases and pathological conditions, the likelihood of which is higher with a certain set of symptoms in people of different sex and age.
Clinical is a rash that looks like flat warts. Their size is quite large. Slightly rise above the surface of the skin. More often these warts are multiple, merge with each other. Merged formations look like plaques. They are located in groups or linearly (in places of injuries and scratching of the skin). The color can be different. from the color of unchanged skin to yellowish or brown. Favorite localization. skin of the face, torso, limbs. If the rashes are localized on the trunk, then in appearance they resemble pityriasis versicolor.
In rare cases, there are areas of limited hyperkeratosis, dyschromia, alopecia. Patients are not considered contagious for immunocompetent people. Based on the clinical picture and anamnesis. Histological examination shows acanthosis, papillomatosis, hyperkeratosis, koilocytosis, accumulations of keratohyalin granules, vertical foci of parakeratosis. HPV typing and genetic testing are recommended.
Less often, the process begins with the skin of the face, neck or torso. The number of warts gradually increases, they merge and occupy almost the entire surface of the skin.
Modern methods of family planning also make it possible to establish the presence of pathology in the fetus. With their help, future parents can independently decide on the preservation of pregnancy. The main clinical symptom of Lewandowski-Lutz disease is the generalized formation of flat urso warts on the skin. At first, the elements are small in size (1-5 mm) and occur mainly on the shins, forearms and hands.
If both the father and the mother showed clinically warty epidermodysplasia, then the risk of developing pathology in their children is 100 percent. If two parents are carriers of the disease genes, then the risk of having a sick child is 25%. If one of the parents has a disease, and an absolutely healthy second, then half of the children will be asymptomatic carriers of the pathology gene, and the second part will not inherit it. If only one parent has the gene for Lewandowski-Lutz disease, then none of ursodiol will get sick, but 25% of them will also become asymptomatic carriers.
Active infection of the skin with papillomavirus leads directly to the development of pathology, which clinicians divide into two groups. Usually, infection with the virus occurs in early childhood due to the widespread distribution of the pathogen. In 90% of patients, the first symptoms occur before the age of 25. Additionally stimulates the development of warty epidermodysplasia ultraviolet radiation of artificial or natural (sun) origin.